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石晓明, 赵伟, 杨永宾等. 结直肠癌组织中赖氨酰氧化酶的表达与肿瘤进展及预后的关系[J]. koko体育app 学报（医学版）, 2017, 48(4): 566-569.
引用本文: 石晓明, 赵伟, 杨永宾等. 结人体宫颈癌组织开展中赖氨酰空气氧化酶的表示与良性肿瘤近况及继发性的感情[J]. 安徽综合大学学报（医药学版）, 2017, 48(4): 566-569.
SHI Xiaoming, ZHAO Wei, YANG Yongbin. et al. Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis[J]. Journal of Sichuan University (Medical Sciences), 2017, 48(4): 566-569.
Citation: SHI Xiaoming, ZHAO Wei, YANG Yongbin. et al. Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis[J]. Journal of Sichuan University (Medical Sciences), 2017, 48(4): 566-569.

结直肠癌组织中赖氨酰氧化酶的表达与肿瘤进展及预后的关系

Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis

  • 摘要: 目的分析结直肠癌组织中赖氨酰氧化酶（LOX）的表达与患者临床病理特征及预后的关系，并探讨LOX在结直肠癌进展中的作用。方法收集2009年1月至2010年5月在我院确诊并行肿瘤切除的82例结直肠癌患者的癌组织、癌旁组织石蜡标本及临床资料、随访信息。免疫组化染色检测结直肠癌及癌旁组织中LOX、缺氧诱导因子-1α（HIF-1α）、基质金属蛋白酶-2（MMP-2）、MMP-7蛋白的表达情况。分析LOX与患者临床病理参数及预后的关系，进一步探讨LOX与HIF-1α、MMP-2、MMP-7之间的关系。结果结直肠癌组织中LOX表达率较癌旁组织高（P<0.05）。LOX表达阳性的患者肿瘤临床分期更晚、浸润深度更深、淋巴结转移更多（P均<0.05）；预后分析显示LOX表达阳性患者的预后较差，COX模型显示LOX表达和TNM分期Ⅲ~Ⅳ期是影响结直肠癌患者预后的独立危险因素（P<0.05）。结直肠癌组织HIF-1α、MMP-2、MMP-7阳性表达率高于癌旁组织（均P>0.05）。相关分析显示LOX表达与HIF-1α、MMP-2蛋白之间存在正相关（P<0.05）。结论LOX蛋白在结直肠癌组织中表达增强，与结直肠癌的进展有关，且可作为预后预测因子。LOX可能与HIF-1α、MMP-2共同作用促进结直肠癌进展。  
    Abstract: Objective To analyze the expression of lysyl oxidase (LOX) in colorectal cancer and its relationship with clinicopathological characteristics, prognosis, and its progress. Methods 82 cases of colorectal tumor paraffin-embedded specimens and paired tumor-adjacent tissues were collected, and data of clinicopathological characteristics and prognosis of these patients were also recorded from 2009.1 to 2010.5. Expressions of LOX, hypoxia inducible factor-1α (HIF-1α), matrix metalloproteinase (MMP)-2, MMP-7 were determined by immunohistochemistry. Then relationship between LOX and clinicopathological characteristics and prognosis was explored, and relationship between LOX and HIF-1α, MMP-2, MMP-7 were investigated. Results Expressions of LOX was stronger in tumors than in tumor-adjacent tissues (P<0.05). Cancer tissues with overexpressed LOX had later clinical stages, deeper tumor invasion, and more metastatic lymph nodes (all P<0.05). The result also showed that patients with overexpression of LOX had poorer prognosis, and overexpression of LOX was independent factor for prognosis in COX survival analysis. Expression of HIF-1α, MMP-2, MMP-7 in colorectal cancer was stronger than in tumor-adjacent tissues (P<0.05). Positive relationship was found between LOX and HIF-1α, MMP-2, MMP-7 proteins (P<0.05). Conclusion LOX was overexpressed in colorectal cancer tissues, and was associated with the progression of colorectal cancer. LOX may be involved in the progress of colorectal cancer by regulating HIF-1α, MMP-2, MMP-7 protein expression.  
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