koko体育app

欢迎来到《koko体育app 学报（医学版）》
李婷婷, 王红静. UCH-L3在上皮性卵巢癌中的表达及临床意义[J]. koko体育app 学报（医学版）, 2019, 50(4): 556-560.
引用本文: 李婷婷, 王红静. UCH-L3在上皮性卵泡癌中的体现及临床治疗意议[J]. 湖北大学本科学报（医疗版）, 2019, 50(4): 556-560.
LI Ting-ting, WANG Hong-jing. UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance[J]. Journal of Sichuan University (Medical Sciences), 2019, 50(4): 556-560.
Citation: LI Ting-ting, WANG Hong-jing. UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance[J]. Journal of Sichuan University (Medical Sciences), 2019, 50(4): 556-560.

UCH-L3在上皮性卵巢癌中的表达及临床意义

UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance

  • 摘要:
      目的  了解泛素羧基末端水解酶3(UCH-L3)在上皮性卵巢癌(EOC)组织中的表达，分析UCH-L3与EOC患者的临床病理特征及预后的关系。
      方法  通过免疫组化染色方法检测不同卵巢组织中UCH-L3的表达，包括正常卵巢组织20例(正常卵巢组)、上皮性卵巢肿瘤组织26例(良性卵巢肿瘤组)、交界性上皮性卵巢肿瘤组织22例(交界性卵巢肿瘤组)、EOC组织61例(EOC组)，分析UCH-L3的表达与EOC患者临床特征及预后的关系。
      结果  UCH-L3在EOC组卵巢组织中的表达高于良性卵巢肿瘤组和正常卵巢组(P均＜0.05)。UCH-L3在EOC中的FIGO晚期组、分化程度高级别组、有腹腔内转移组中的表达高于FIGO早期组(P=0.006)、分化程度低级别组(P=0.001)和无腹腔内转移组(P=0.032)。UCH-L3在EOC患者肿瘤组织高、低表达组间的生存时间差异无统计学意义。
      结论  UCH-L3在EOC发生发展中可能有一定作用，但与患者的预后无关。
     
    Abstract:
      Objective  To study the expression of ubiquitin C-terminal hydrolase-L3 (UCH-L3) in epithelial ovarian cancer (EOC) tissues, and to analyze the relationship between UCH-L3 expression and the clinic pathological characteristics and prognosis of EOC patients.
      Methods  Immunohistochemical analysis was performed to evaluate UCH-L3 expression in different ovarian epithelial tissue specimens. The correlation between UCH-L3 expression and clinical pathologic parameters, prognosis and of EOC was statistically analyzed.
      Results  The expression level of UCH-L3 in EOC was higher than that in benign ovarian tumor and normal ovary (P < 0.05). The positive expression level of UCH-L3 in late FIGO group, high-level group, group with intraperitoneal metastasis were significantly higher than that in early FIGO group (P=0.006), low-level group (P=0.001), group without intraperitoneal metastasis (P=0.032). There was no significant difference in survival time between the high and low expression groups of UCH-L3.
      Conclusion  UCH-L3 may play a role in EOC pathogenesis and progression.
     
    • HTML全文
© 2019 《koko体育app 学报（医学版）》编辑部　版权所有 cc

开放获取♊ 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问

/

返回文章
返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!