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杨晋军, 陈心传, 唐韫等. 血管内大B细胞淋巴瘤17例临床分析[J]. koko体育app 学报（医学版）, 2018, 49(1): 145-147.
引用本文: 杨晋军, 陈心传, 唐韫等. 腮腺管内大B细胞系腮腺瘤17例诊疗分折[J]. 贵州大学生学报（医美版）, 2018, 49(1): 145-147.
YANG Jin-jun, CHEN Xin-chuan, TANG Yun. et al. Intravascular Large B-cell Lymphoma: a Clinical Analysis of 17 Cases[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(1): 145-147.
Citation: YANG Jin-jun, CHEN Xin-chuan, TANG Yun. et al. Intravascular Large B-cell Lymphoma: a Clinical Analysis of 17 Cases[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(1): 145-147.

血管内大B细胞淋巴瘤17例临床分析

Intravascular Large B-cell Lymphoma: a Clinical Analysis of 17 Cases

  • 摘要: 目的 分析血管内大B细胞淋巴瘤的临床特点、治疗及预后。方法 回顾性分析koko体育app 华西医院血液科2009年2月至2015年7月诊治的17例血管内大B细胞淋巴瘤患者的临床资料，并进行生存分析。结果 纳入患者17例，男10例，女7例，发病年龄24~83岁，平均53岁；反复发热是患者最常见的首发症状（76.5%），骨髓是最易累及的部位（64.7%），临床分期多为ⅣB期（70.6%），常合并噬血细胞综合征（29.4%）。R-CHOP（利妥昔单抗、环磷酰胺、表阿霉素、长春地辛、强的松）或CHOP方案化疗（10例）可以显著改善患者的生存时间（与未治疗的7例患者相比，P=0.000 2）。骨髓受累的患者治疗后易复发。结论 血管内大B细胞淋巴瘤侵袭性强，预后差。R-CHOP方案化疗可以显著改善患者的预后，治疗后获得完全缓解的患者进行自体造血干细胞移植，可能在长期生存上获益。  
    Abstract: Objective To analyze the clinical features, response to therapy and prognosis of intravascular large B-cell lymphoma (IVLBCL). Methods The clinical data of 17 cases with IVLBCL were retrospectively reviewed, and survival analysis was conducted. Results The study involved 10 males and 7 females of IVLBCL with a mean age of 53 years old. The most common symptom of the disease was recurrent fever (76.5%). The lymphoma was mainly observed in bone marrow (64.7%) and was clinically determined as stage ⅣB (70.6%). Many of the patients were also diagnosed with the hemophagocytic syndrome (29.4%). R-CHOP (rituximab, cyclophosphamide, epirubicin, vindesine, prednisone) or CHOP regimen chemotherapy significantly improved the survival of the patients (P=0.000 2). Unfortunately, those patients with bone marrow involvement were prone to relapse after treatment. Conclusion IVLBCL is highly invasive and associated with poor prognosis. R-CHOP chemotherapy can significantly improve the prognosis.  
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