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杨正国, 吴仲, 彭兵等. 免疫性血小板减少性紫癜患者幽门螺旋杆菌的检测及其临床意义[J]. koko体育app 学报（医学版）, 2014, 45(2): 348-350.
引用本文: 杨正国, 吴仲, 彭兵等. 免役性小血板极大减少性紫癜患有幽门螺旋式杆菌的探测及诊疗含义[J]. 江苏社会学报（医学研究版）, 2014, 45(2): 348-350.

免疫性血小板减少性紫癜患者幽门螺旋杆菌的检测及其临床意义

  • 摘要: 目的 分析幽门螺旋杆菌 （HP）在免疫性血小板减少性紫癜 （ITP）患者脾脏中的存在情况及与临床相关性。方法 纳入koko体育app 华西医院肝胆胰外科42例行腹腔镜脾切除术的ITP患者 （男10例，女32例，平均年龄36.4岁），另纳入10例行外伤性脾破裂行脾切除术的患者 （男8例，女2例，平均年龄36.6岁）作为正常对照组。采用C 14呼气实验检测ITP患者的HP感染情况，对患者手术切除的脾脏标本切片后进行HP免疫组织化学染色及吉姆萨染色，并结合患者临床资料进行分析。结果 42例ITP患者中HP感染者为36例 (85.7%)，正常对照组中HP感染者为3 (30%)例；ITP组HP免疫组化阳性为12例，正常对照组HP免疫组化阳性为1例。对ITP患者的脾脏组织切片行吉姆萨染色，部分切片结果为可疑阳性，正常对照组均为阴性。感染HP的ITP患者中，无ITP轻度，中度为4例，重度为7例，极重度为25例。未感染HP的ITP患者中，无轻度患者，中度、重度和极重度分别均为2例。结论 在ITP患者的脾脏组织中证实有病原体HP的存在。HP感染与ITP患病的严重程度相关。  
    Abstract: 【Abstract】 Objective To observe the efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) transplantation for the patients with refractory systemic lupus erythematosus (SLE)． Methods Thirty seven patients with SLE were enrolled in this study, and divided into conventional treatment group (control group, n=20) and UC-MSCS adjuvant treatment group (treatment group, n=17). All the patients in both two groups were treated with glucocorticoids and cyclophosphamide (CTX). In the UC-MSCs group, each patient additionally received the transplantation of 3×107UC-MSCs infusion intravenously. The clinical manifestations and laboratory parameters of each patient were observed before the treatments and 2 weeks, 1 month, 2 months, 3 months, 6 months, 9 months and 12 months after the treatments. Results All the 37 patients were observed for 12 months. 24 h urinary protein excretion (U-Pro), anti nuclear antibody (ANA), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), systemic lupus erythematosus disease activity index (SLEDAI) of these two groups decreased significantly (P<0.05). serum albumin (ALB), C3, and C4 of two groups were higher after the treatments (P<0.05). ALB and C3 in treatment group exceeded the control group (P<0.05). The positive rates of Anti-dsDNA in control and treatment group were 40% and 10% respectively, while the recurrence rates were 50% and 20% respectively, these difference between the two groups were statistically significant (P<0.05). There were no transplantation related complications observed. Conclusion UC-MSCs transplantation could be effective and safe for refractory SLE on basis of glucocorticoid and cyclophosphamide therapy.  
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