koko体育app

欢迎来到《koko体育app 学报（医学版）》
魏瑷琳, 郭强, 龚姝. TWEAK/Fn14蛋白在胰腺癌组织中的表达[J]. koko体育app 学报（医学版）, 2017, 48(1): 154-157.
引用本文: 魏瑷琳, 郭强, 龚姝. TWEAK/Fn14淀粉酶在胰腺癌组织性中的描述[J]. 重庆读书学报（医美版）, 2017, 48(1): 154-157.

TWEAK/Fn14蛋白在胰腺癌组织中的表达

  • 摘要: 目的 通过检测并比较肿瘤坏死因子样凋亡弱诱导剂（TWEAK）和人成纤维细胞生长因子诱导型14（Fn14）在正常胰腺组织、慢性胰腺炎及胰腺癌组织中的表达，分析探讨TWEAK/Fn14通路在胰腺癌发展过程中的作用。方法 收集在koko体育app 华西医院胰腺外科行手术治疗、切除的胰腺组织标本，并经病理检察证实，胰腺癌标本50例，慢性胰腺炎标本40例，正常胰腺组织标本30例。采用免疫组化检测胰腺组织中TWEAK和Fn14的表达，并分析TWEAK表达与胰腺癌临床病理特征的关系。结果 TWEAK阳性表达率在胰腺癌为36.0%（18/50），高于慢性胰腺炎17.5%（7/40）及正常胰腺组织13.3%（4/30），组间差异有统计学意义（ P<0.05），表达强度亦为胰腺癌组织＞慢性胰腺炎＞正常胰腺组织（ P<0.05）。Fn14在胰腺癌组织（4.0%）和正常胰腺组织（7.0%）阳性表达率低，胰腺炎组织中未发现阳性表达。TWEAK阳性表达率和高表达率在Ⅱ期患者中随着肿瘤疾病分级增加而增加（ P<0.05）。而各病理分级中，TWEAK阳性表达率、高表达率和EI评分的差异均无统计学意义。结论 TWEAK/Fn14参与了胰腺癌的发生发展过程。TWEAK在胰腺癌中高表达，Fn14呈低表达。  
    Abstract: Objective To investigate the effect of tumor necrosis factor -related weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) on the proliferation and growth of pancreatic cancer. Methods Human pancreatic cancer (50 cases), chronic pancreatitis (40 cases) and normal pancreatic tissues (30 cases) were collected in West China Hospital from January 2012 to December 2013. TWEAK and Fn14 expressions in these tissues were checked with hematoxylin-eosin (HE) staining and immunohistochemistry method. Relationship between TWEAK expression and clinicopathological features of pancreatic cancer was analyzed. Results TWEAK expression rate was 36% (18/50) in pancreatic cancer, higher than that in chronic pancreatitis (17.5%, 7/40) and normal pancreatic tissues (13.3%, 4/30) ( P<0.05) .Expression intensity of TWEAK in three groups was also obviously ( P<0.05). The expression rate of Fn14 was 4.0% in pancreatic cancer ,7.0% in normal pancreatic tissues ,and 0% in chronic pancreatitis. TWEAK positive expression rate and high expression rate in pancreatic cancer were higher in IIB group ( P<0.05). Pathological grade was not related to TWEAK expression. Conclusion TWEAK/Fn14 involved in the progression of pancreatic cancer. In the tissue of pancreatic cancer, TWEAK was highly expressed, and Fn14 was lowly expressed.  
    • HTML全文
© 2017 《koko体育app 学报（医学版）》编辑部　版权所有 cc

开放获取🅺 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问

/

返回文章
返回
var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.src = "https://hm.baidu.com/hm.js?90c4d9819bca8c9bf01e7898dd269864"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); !function(p){"use strict";!function(t){var s=window,e=document,i=p,c="".concat("https:"===e.location.protocol?"https://":"http://","sdk.51.la/js-sdk-pro.min.js"),n=e.createElement("script"),r=e.getElementsByTagName("script")[0];n.type="text/javascript",n.setAttribute("charset","UTF-8"),n.async=!0,n.src=c,n.id="LA_COLLECT",i.d=n;var o=function(){s.LA.ids.push(i)};s.LA?s.LA.ids&&o():(s.LA=p,s.LA.ids=[],o()),r.parentNode.insertBefore(n,r)}()}({id:"K9y7iMpaU8NS42Fm",ck:"K9y7iMpaU8NS42Fm"}); koko体育-koko体育app koko体育-koko体育网页版koko体育app koko体育-全站app下载(官网) m6米乐app|下载 m6米乐app|主頁欢迎您!!