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肌酸代谢的化学交换饱和位移成像：3.0T MRI初步研究
Chemical Exchange Saturation Transfer Imaging of Creatine Metabolites: a 3.0 T MRI Pilot
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摘要: 目的 探讨3.0T MRI化学交换饱和位移成像技术（chemical exchange saturation transfer，CEST）对肌酸代谢成像的可行性及相关影响因素。方法 准备不同浓度肌酸及其代谢产物的体外模型和不同pH值的肌酸及其对照组体外模型。采用3.0T MRI 对这两组模型进行CEST成像，通过CEST效应及Z谱进行量化分析。结果 3.0T MRI可检测到不同浓度肌酸之间信号（±1.8 ppm）差异明显（F=99.08, P<0.001），且信号强度随着浓度增加而增强（r=0.963， P<0.001）。另外，不同pH值环境CEST效应差异明显（F=5.539, P=0.002），信号随pH值下降而逐渐减低（ r=0.41，P=0.035）。结论 3.0T MRI进行CEST成像评价肌酸代谢是可行的，且其CEST效应受肌酸浓度及代谢环境pH值等因素影响。Abstract: Objective To determine the feasibility of using chemical exchange saturation transfer (CEST) imaging to measure creatine (Cr) metabolites with 3.0 T MR. Methods Phantoms containing different concentrations of Cr under various pH conditions were studied with CEST sequence on 3.0 T MR imaging. CEST effect and Z spectra were analyzed. Results Cr exhibited significant CEST effect (±1.8 ppm, F=99.08, P<0.001) on 3.0 T MR imaging, and positive correlation was found between the signal intensity and concentration of Cr ( r =0.963， P<0.001). The CEST effect showed pH dependency of Cr ( r =0.41， P=0.035). Conclusion Creatine CEST imaging can be performed on 3.0 T MR imaging. Creatine concentrations and pH influence CEST effect.
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